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CYP11B2-IN-2

CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC50 of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism[1].

Product Specifications

CAS Number

2241573-22-6

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyp11b2-in-2.html

Smiles

FC1=CC(C2=CC(C3(C)OCCO3)=CN=C2)=CC=C1C#N

Molecular Formula

C16H13FN2O2

Molecular Weight

284.29

References & Citations

[1]Maier P, et al., Fluorinated aldosterone synthase (CYP11B2) -inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism. Bioorg Med Chem Lett. 2023 Nov 15;96:129501.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP11

Frequently Asked Questions

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