(Rac) -PT2399
(Rac) -PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1].
Product Specifications
CAS Number
1672662-07-5
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-pt2399.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C(F)F)=O)C3=C2CC(F)(F)C3O)=C1
Molecular Formula
C17H10F5NO4S
Molecular Weight
419.32
References & Citations
[1]Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S) -3- ((2,2-Difluoro-1-hydroxy-7- (methylsulfonyl) -2,3-dihydro-1 H-inden-4-yl) oxy) -5-fluorobenzonitrile (PT2385) . J Med Chem. 2018 Nov 8;61 (21) :9691-9721.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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