JQ-1 (carboxylic acid)
Product Specifications
UNSPSC Description
JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.
Target Antigen
Epigenetic Reader Domain; PD-1/PD-L1
Type
Reference compound
Related Pathways
Epigenetics;Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JQ-1-carboxylic-acid.html
Purity
99.82
Solubility
DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(O)=O)C=C1
Molecular Weight
400.88
References & Citations
[1]Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33(1):142-151.|[2]Chen W, et, al. Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses. Biomaterials. 2022 Jul;286:121582.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-78695/JQ-1-carboxylic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-78695/JQ-1-carboxylic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
202592-23-2
Available Sizes
Curated Selection
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