JQ-1 (carboxylic acid)

JQ-1 carboxylic acid, a (+) -JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

Product Specifications

CAS Number

[202592-23-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain; PD-1/PD-L1

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/JQ-1-carboxylic-acid.html

Purity

99.69

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(O)=O)C=C1

Molecular Formula

C19H17ClN4O2S

Molecular Weight

400.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33 (1) :142-151.|[2]Chen W, et, al. Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses. Biomaterials. 2022 Jul;286:121582.