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Recombinant PHOX2B Antibody

Paired homeobox protein 2B (PHOX2B) is a transcription factor located on chromosome 4p13, which is essential for the formation of autonomic ganglia in the autonomic nervous system. PHOX2B is expressed in neuroblastoma, brain and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2) .

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q99453

Host

Rabbit

Reactivity

Human

Immunogen

A human PHOX2B partial protein was used as the immunogen for the recombinant PHOX2B antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG κ

Clone

PHOX2B/7161R

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the recombinant PHOX2B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This recombinant PHOX2B antibody is available for research use only.

Storage Conditions

Aliquot the recombinant PHOX2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the recombinant PHOX2B antibody should be determined by the researcher.

Location

Nucleus

Image Legend

IHC staining of FFPE human renal cell carcinoma with recombinant PHOX2B antibody (clone PHOX2B/7161R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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