Recombinant PDCD1 Antibody / PD-1 / PD1

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 2-4 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q15116

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1-200 from the human protein was used as the immunogen for the recombinant PDCD1 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

PDCD1/7125

Applications

WB, IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the recombinant PDCD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This recombinant PDCD1 antibody is available for research use only.

Storage Conditions

Aliquot the recombinant PDCD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the recombinant PDCD1 antibody should be determined by the researcher.

Location

Cell surface, cytoplasm

Image Legend

Western blot testing of human tonsil and brain tissue lysate with recombinant PDCD1 antibody. Predicted molecular weight: 32-55 kDa depending on glycosylation level.