MUC5B Antibody

Mucin 5B (MUC5B/Muc5b) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in mouse. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 2-5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL

UniProt

Q9HC84

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant human protein (amino acids A5688-V5762) was used as the immunogen for the MUC5B antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

IHC-P, Direct ELISA

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Reconstitution

After reconstitution, the MUC5B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This MUC5B antibody is available for research use only.

Storage Conditions

After reconstitution, the MUC5B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the MUC5B antibody should be determined by the researcher.

Image Legend

IHC staining of FFPE human rectal cancer tissue with MUC5B antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.