DOCK2-IN-1

DOCK2-IN-1 (compound 3), a CPYPP analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].

Product Specifications

CAS Number

4590-86-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DOCK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dock2-in-1.html

Concentration

10mM

Purity

98.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3

Molecular Formula

C16H11ClN2O2

Molecular Weight

298.72

Precautions

H302, H315, H319

References & Citations

[1]Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19 (4) :488-97.