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Pregnenolone monosulfate-d4 (sodium)

Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

Product Specifications

CAS Number

1485492-21-4

Product Name Alternative

3β-Hydroxy-5-pregnen-20-one monosulfate-d4 (sodium)

UNSPSC

12352100

Target

Autophagy; Cannabinoid Receptor; Endogenous Metabolite; Isotope-Labeled Compounds; TRP Channel

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OS(=O)(O[Na])=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([2H])C(C([2H])([2H])[2H])=O)C

Molecular Formula

C21H27D4NaO5S

Molecular Weight

422.55

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2] Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641 (2-3) :128-34.|[3]Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14 (1) :7.|[4]Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343 (6166) :94-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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