Rostratin A

Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 of 8.5 μg/mL[1].

Product Specifications

CAS Number

[752236-16-1]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rostratin-a.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@]([C@H](CC2)O)([H])[C@]([C@H]2O)([H])C3)[C@@]4(SS[C@]13C5=O)N5[C@@]([C@H](CC6)O)([H])[C@]([C@H]6O)([H])C4

Molecular Formula

C18H24N2O6S2

Molecular Weight

428.52

References & Citations

[1]Tan RX, et al. Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. J Nat Prod. 2004;67 (8) :1374-1382.