POPG (sodium salt)

POPG sodium salt is a negatively charged phospholipid. POPG sodium salt affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG sodium salt increases the apparent affinity of Gαq and Gβ1γ1 for activated NTS1. POPG sodium salt can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research[1][2][3][4].

Product Specifications

CAS Number

[268550-95-4]

Product Name Alternative

PG (16:0/18:1) ; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho- (1'-rac-glycerol)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H331, H336, H351, H361, H372, H412

Target

Biochemical Assay Reagents; Liposome; Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-1-rac-glycerol-sodium-salt.html

Purity

99.23

Solubility

DMSO : 18.18 mg/mL (ultrasonic; adjust pH to 4 with 1 M HCl) |Ethanol : 8.33 mg/mL (ultrasonic)

Smiles

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(OCC(O)CO)(O[Na])=O)COC(CCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C40H76NaO10P

Molecular Weight

770.99

Precautions

H302, H315, H319, H331, H336, H351, H361, H372, H412

References & Citations

[1]Kim MR, et al. Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles. Polymers (Basel) . 2019;11 (2) :288. Published 2019 Feb 8. |[2]Inagaki S, et al. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. J Mol Biol. 2012 Mar 16;417 (1-2) :95-111. |[3]Zhao L, et al. Molecular Dynamics Simulations of Human Antimicrobial Peptide LL-37 in Model POPC and POPG Lipid Bilayers. Int J Mol Sci. 2018 Apr 13;19 (4) :1186. |[4]Agrawal N, et al. Investigating the Effects of the POPC-POPG Lipid Bilayer Composition on PAP248-286 Binding Using CG Molecular Dynamics Simulations. J Phys Chem B. 2023 Oct 26;127 (42) :9095-9101.