3,4-Dimethoxychalcone

3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs) . 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1].

Product Specifications

CAS Number

[5416-71-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-4-dimethoxychalcone.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=CC=C(OC)C(OC)=C2

Molecular Formula

C17H16O3

Molecular Weight

268.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11 (1) :21781.|[2]Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11 (11) :e10469.