Tomatine

Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.) . Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].

Product Specifications

CAS Number

[17406-45-0]

Product Name Alternative

α-Tomatine; Lycopersicin; Tomatin

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Proteasome

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tomatine.html

Purity

99.90

Solubility

DMSO : 43.75 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@@]34CC[C@H](C)CN4)([H])C[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]%10O)O)([H])O[C@@H]%10CO)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2

Molecular Formula

C50H83NO21

Molecular Weight

1034.19

Precautions

H302

References & Citations

[1]da Silva DC, et al. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017 Jul;171:178-186.