Anti-Hu CD329 Alexa Fluor® 488
CD329 is a type I transmembrane glycoprotein of siglec family, which contains intracellular ITIM motif, and a SLAM-like motif, that acts as a docking site for SAP. CD329 can regulate TCR signaling by recruitment of SHP-1, which results in down-regulation of TCR-based gene transcription. It is expressed above all on monocytes, neutrophils, and a minor population of CD16+CD56- cells, weaker expression is detectable in some B cells, NK cells, and T cells.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant CD329-Hu IgGFc fusion protein
Target Antigen
CD329
Clone
K8
Applications
FC (QC tested), ICC
Format
Alexa Fluor® 488
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*O'Sullivan JA, Carroll DJ, Cao Y, Salicru AN, Bochner BS: Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. J Allergy Clin Immunol. 2018 May;141 (5) :1774-1785, URL: https://pubmed.ncbi.nlm.nih.gov/28734845/, *Hudak JE, Canham SM, Bertozzi CR: Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nat Chem Biol. 2014 Jan;10 (1) :69-75., URL: https://pubmed.ncbi.nlm.nih.gov/24292068/, *Avril T, Floyd H, Lopez F, Vivier E, Crocker PR: The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. J Immunol. 2004 Dec 1;173 (11) :6841-9. , URL: https://pubmed.ncbi.nlm.nih.gov/15557178/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody K8 recognizes an extracellular epitope of CD239, a type I transmembrane glycoprotein expressed above all on monocytes, neutrophils, and a minor population of CD16+CD56- cells.
Applications Notes
6
Isotype
Mouse IgG1 kappa
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