SMCA5 rabbit pAb

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

O60264

Swiss Prot

O60264

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human SMCA5 AA range: 851-901

Target

SMCA5

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Chromosome . Localizes to mitotic chromosomes (PubMed:12972596) . Co-localizes with RSF1 in the nucleus (PubMed:12972596) . Co-localizes with PCNA at replication foci during S phase (PubMed:15543136) . Co-localizes with BAZ1B/WSTF at replication foci during late-S phase (PubMed:15543136) . Recruited to DNA damage sites following interactiuon with SIRT6 (PubMed:23911928) . .