GAK inhibitor 49
GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1].
Product Specifications
CAS Number
[319492-82-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclin G-associated Kinase (GAK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gak-inhibitor-49.html
Concentration
10mM
Purity
98.79
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1
Molecular Formula
C20H22N2O5
Molecular Weight
370.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13 (1) :48-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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