GAK inhibitor 49

GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1].

Product Specifications

CAS Number

[319492-82-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cyclin G-associated Kinase (GAK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gak-inhibitor-49.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1

Molecular Formula

C20H22N2O5

Molecular Weight

370.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13 (1) :48-66.