Demycarosyl-3D-β-D-digitoxosylmithramycin SK
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins[1].
Product Specifications
CAS Number
[1262896-48-9]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/demycarosyl-3d-β-d-digitoxosylmithramycin-sk.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1O[C@H](O[C@@H]2C)C[C@H]([C@@H]2O)O[C@H](O[C@@H]3C)C[C@H]([C@H]3O)O[C@H](O[C@@H]4C)C[C@@H]([C@@H]4O)O)C(C(C[C@@]1([H])[C@H](OC)[C@@H](O)C(C)=O)=CC5=CC(O[C@H](O[C@@H]6C)C[C@H]([C@@H]6O)O[C@H](O[C@@H]7C)C[C@H]([C@@H]7O)O)=C8C)=C(C5=C8O)O
Molecular Formula
C50H72O23
Molecular Weight
1041.09
References & Citations
[1]Núñez, et al. A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis. Journal of Medicinal Chemistry, 55 (12), 5813-5825.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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