Demycarosyl-3D-β-D-digitoxosylmithramycin SK

Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins[1].

Product Specifications

CAS Number

[1262896-48-9]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/demycarosyl-3d-β-d-digitoxosylmithramycin-sk.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1O[C@H](O[C@@H]2C)C[C@H]([C@@H]2O)O[C@H](O[C@@H]3C)C[C@H]([C@H]3O)O[C@H](O[C@@H]4C)C[C@@H]([C@@H]4O)O)C(C(C[C@@]1([H])[C@H](OC)[C@@H](O)C(C)=O)=CC5=CC(O[C@H](O[C@@H]6C)C[C@H]([C@@H]6O)O[C@H](O[C@@H]7C)C[C@H]([C@@H]7O)O)=C8C)=C(C5=C8O)O

Molecular Formula

C50H72O23

Molecular Weight

1041.09

References & Citations

[1]Núñez, et al. A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis. Journal of Medicinal Chemistry, 55 (12), 5813-5825.