HDHODH-IN-3
HDHODH-IN-3 (compound 21d) is a human dihydroorotate dehydrogenase (HsDHODH) inhibitor, inhibits measles virus replication with a pMIC50 value of 8.6[1].
Product Specifications
CAS Number
1644156-80-8
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhodh-in-2.html
Purity
99.97
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CCC1=CN=C(N2N=C(OCC)C(OC3=CC=CC=C3Br)=C2C)N=C1
Molecular Formula
C18H19BrN4O2
Molecular Weight
403.27
References & Citations
[1]Lucas-Hourani M, et al. Original 2- (3-Alkoxy-1H-pyrazol-1-yl) azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) .J Med Chem. 2015 Jul 23;58 (14) :5579-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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