Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model[1].
Product Specifications
CAS Number
3036050-96-8
UNSPSC
12352005
Target
NF-κB; p38 MAPK; RANKL/RANK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/anti-osteoporosis-agent-8.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=NC=C1)C([Se]C2=CC=CC=C2)C(C)(OCC(F)(F)F)C
Molecular Formula
C18H19F3N2O2Se
Molecular Weight
431.31
References & Citations
[1]Wu Y, et al., Design, Synthesis, and Biological Evaluation of β-Trifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents. J Med Chem. 2024 May 9;67 (9) :7585-7602.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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