STX140

STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities[1].

Product Specifications

CAS Number

[401600-86-0]

UNSPSC

12352100

Target

Apoptosis; Estrogen Receptor/ERR; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stx140.html

Smiles

C[C@@]12[C@](CC[C@@H]2OS(N)(=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(OC)=C(OS(N)(=O)=O)C=C4CC3

Molecular Formula

C19H28N2O7S2

Molecular Weight

460.56

References & Citations

[1]S P Newman, et al. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. Br J Cancer. 2007 Dec 17;97 (12) :1673-82.