D (+) -Galactosamine (hydrochloride)

D (+) -Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D (+) -Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D (+) -Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure[1][2].

Product Specifications

CAS Number

[1772-03-8]

Product Name Alternative

D-Galactosamine HCl

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/d-plus-galactosamine-hydrochloride.html

Purity

99.94

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1[C@H](N)[C@@H](O)[C@@H](O)[C@@H](CO)O1.[H]Cl

Molecular Formula

C6H14ClNO5

Molecular Weight

215.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Li Y, et al. Inhibition of PI3K/AKt/mTOR signaling pathway protects against d-galactosamine/lipopolysaccharide-induced acute liver failure by chaperone-mediated autophagy in rats. Biomed Pharmacother. 2017 Aug;92:544-553. |[2]Liu Y, et al. AMSC-derived exosomes alleviate lipopolysaccharide/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages. EBioMedicine. 2018 Oct;36:140-150.|[3]Siendones E, et al. PGE1 abolishes the mitochondrial-independent cell death pathway induced by D-galactosamine in primary culture of rat hepatocytes. J Gastroenterol Hepatol. 2005 Jan;20 (1) :108-16. |[4]Keppler D, et al. Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol. 1968 Oct;9 (2) :279-90.