(1R,3S) -RSL3
(1R,3S) -RSL3 is the less active (1R,3S) -enantiomer of RSL3 ((1S,3R) -RSL3) . (1R,3S) -RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 µM and 0.004 µM, rspectively[1].
Product Specifications
CAS Number
[1219810-13-5]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1r-3s-rsl3.html
Purity
99.78
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
Molecular Formula
C23H21ClN2O5
Molecular Weight
440.88
Precautions
H301, H311, H331, H341
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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