(1R,3S) -RSL3

(1R,3S) -RSL3 is the less active (1R,3S) -enantiomer of RSL3 ((1S,3R) -RSL3) . (1R,3S) -RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 µM and 0.004 µM, rspectively[1].

Product Specifications

CAS Number

[1219810-13-5]

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1r-3s-rsl3.html

Purity

99.78

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC

Molecular Formula

C23H21ClN2O5

Molecular Weight

440.88

Precautions

H301, H311, H331, H341

References & Citations

[1]Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.