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Magnesium Lithospermate B

Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin ammation and attenuates neurodegeneration[1][2][3].

Product Specifications

CAS Number

122021-74-3

UNSPSC

12352005

Target

Na+/K+ ATPase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/magnesium-lithospermate-b.html

Purity

99.49

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1[O-][Mg+2]23O=C(/C=C\C4=C5[C@H](C(O[C@H](CC6=CC=C(C(O)=C6)O)C([O-]3)=O)=O2)[C@@H](C7=CC=C(C(O)=C7)O)OC5=C(O)C=C4)O[C@@H]1CC8=CC=C(C(O)=C8)O

Molecular Formula

C36H28MgO16

Molecular Weight

740.90

References & Citations

[1]Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31 (5) :721-728.|[2]Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33 (1) : 85-91.|[3]Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14.|[4]Magnesium lithospermate B possesses inhibitory activity on Na+, K+‐ATPase and neuroprotective effects against ischemic stroke

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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