PDK1-IN-1
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor. PDK1-IN-1 is also useful as inhibitor of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. PDK1-IN-1 selectively inhibits microtubule affinity regulating kinase (MARK) . PDK1-IN-1 can be used for researches of myeloproliferative disorders, cancer and Alzheimer's disease[1].
Product Specifications
CAS Number
[1207836-10-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FGFR; MARK; PDK-1; Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pdk1-in-1.html
Purity
99.95
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CN2C(C(OC)=C1)=C(C=N2)C#N
Molecular Formula
C9H6BrN3O
Molecular Weight
252.07
Precautions
H302, H315, H319, H335
References & Citations
[1]Jason Katz, et al. Therapeutic compounds. Patent. WO2010017047 A1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR3
Available Sizes
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