SMARCA2-IN-6
SMARCA2-IN-6 is a SMARCA2 (also known as BRM) inhibitor, with IC50s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6 inhibits KRT80 gene expression in H1299 cells (IC50: 26 nM) . SMARCA2-IN-6 inhibits proliferation in BRG1-mutant SKMEL5 cells (IC50: 13 nM) [1].
Product Specifications
CAS Number
2270875-79-9
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-in-6.html
Smiles
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2N
Molecular Formula
C10H8ClF2N5OS
Molecular Weight
319.72
References & Citations
[1]Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM) /SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1) /SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61 (22) :10155-10172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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