15 (R) -15-Methyl Prostaglandin F2α
15 (R) -15-Methyl Prostaglandin F2α (15 (R) -Carboprost; 15 (R) -15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15 (R) -15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15 (R) -15-Methyl Prostaglandin F2α converts it into the active 15 (S) -isomer. The 15 (S) -isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15 (R) -isomer does not.
Product Specifications
CAS Number
[35864-81-4]
Product Name Alternative
15 (R) -Carboprost; 15 (R) -15-methyl PGF2α
UNSPSC
12352211
Hazard Statement
H225-H319-H336-H360
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/15-r-15-methyl-prostaglandin-f2α.html
Smiles
CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O
Molecular Formula
C21H36O5
Molecular Weight
368.51
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Hamberg, et al. On the pH-dependent degradation of 15 (S) -15 methyl-prostaglandin F2α (Carboprost) . Eur. J. Pharm. Sci. 3 (1), 27-38 (1995) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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