N-Desmethyl imatinib (mesylate)

N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463) . Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR[1].

Product Specifications

CAS Number

[404844-03-7]

Product Name Alternative

Norimatinib (mesylate) ; Imatinib metabolite N-Desmethyl imatinib (mesylate)

UNSPSC

12352005

Hazard Statement

H302-H312-H332-H341-H351-H373-H412

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-desmethyl-imatinib-mesylate.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(O)=O.O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4

Molecular Formula

C29H33N7O4S

Molecular Weight

575.68

Precautions

P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Robert A Parise, et al. Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791 (1-2) :39-44.