Anti-IL-2RA (CD25) Neutralizing Antibody

IL2RA (interleukin-2 receptor alpha chain), also known as CD25, is one of the subunits of the high affinity IL-2 receptor. IL-2 receptor is composed of IL2RA, IL2RB and IL2RG, and it is crucial for immune cell responses. Il-2 receptors with low and intermediate affinity also exist, controlling the sensitivity of specific cell types to IL-2. IL-2 binding to the IL2R activates downstream pathways, starting with phosphorylation of JAK1 (Janus tyrosine kinase) and JAK3. The understanding and manipulation of the IL-2/IL2R.