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Anti-IL-2RA (CD25) Neutralizing Antibody

This anti-IL2RA (interleukin-2 receptor alpha subunit) antibody is a purified, recombinant human monoclonal which recognizes IL-2RA (also known as CD25) . This affinity purified antibody has been tested for specific binding to the human recombinant protein IL2RA, Avi-His-Tag Recombinant (BPS Bioscience #101203) in a colorimetric ELISA binding assay.

Product Specifications

Background

IL2RA (interleukin-2 receptor alpha chain), also known as CD25, is one of the subunits of the high affinity IL-2 receptor. IL-2 receptor is composed of IL2RA, IL2RB and IL2RG, and it is crucial for immune cell responses. Il-2 receptors with low and intermediate affinity also exist, controlling the sensitivity of specific cell types to IL-2. IL-2 binding to the IL2R activates downstream pathways, starting with phosphorylation of JAK1 (Janus tyrosine kinase) and JAK3. The understanding and manipulation of the IL-2/IL2R.

CAS Number

9007-83-4

UniProt

P01589

Applications

Useful for studying the binding and neutralization of IL-2RA in ELISA and in cellular assays.

Purity

≥ 90%

Format

Aqueous buffer solution

Shipping Conditions

-80°C

Storage Conditions

At least 12 months at -80°C.

Calculated Molecular Weight

Heavy Chain: 50 kDa; Light Chain: 23 kDa + glycans

Formulation

8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Glycosylation

This antibody runs at a higher MW by SDS-PAGE due to glycosylation.

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