Human MIP-3B (CCL23) Recombinant

CCL23 (MPIF-1, CK8, SCYA23), a member of the CC chemokine family, was originally isolated from a human aortic endothelial cell library and from the human monocytic cell line THP-1. It is most closely related to MIP-1 and interacts with its receptor CCR1, which is expressed on monocytes, dendritic cells, lymphocytes, and endothelial cells. Functionally, CCL23 has chemotactic activity for monocytes, DC, lymphocytes, neutrophils, osteoclast precursor cells, and endothelial cells. In contrast, CCL23 reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages, whereas it enhances angiogenesis of endothelial cells.

Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.

The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.