Caspase6, His-tag Recombinant

Caspase 6 is cysteine-aspartic acid protease that plays a central role in the execution of apoptosis (programmed cell death) as part of a sequential caspase activation cascade. Caspase 6 is processed and activated by caspases 7,8, and 10. One of the main functions of caspase 6 is to cleave cytoskeletal proteins, such as lamin A and fodrin, leading to cytoskeletal disruption and cell shrinkage to facilitate the breakdown of the cellular architecture involved in membrane blebbing and nuclear condensation that are characteristic of apoptosis. It also cleaves proteins involved in DNA repair and RNA processing. Caspase 6 has been implicated in neurodegenerative diseases such as Alzheimer's disease and may be involved in the abnormal accumulation of misfolded amyloid-beta. It has also been shown to cleave neuron protein Tau.