Anti-CD47 Antagonist Antibody
Recombinant human anti-CD47 antagonist antibody recognizing the SIRP-α or SIRP-ү binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.
Product Specifications
Background
CD47 (Cluster of Differentiation 47) plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a “do not eat me” signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system. CD47 signal-regulatory protein alpha (SIRP-α), also known as CD172a, is a cell surface protein expressed mainly by myeloid cells such as macrophages. In the context of a tumor, this signaling aids in tumor evasion of the immune system. Inhibitors of this interaction hold great promise for cancer immunotherapy.
Purification
Protein A affinity chromato-graphy from HEK293 supernatants.
Shipping Conditions
-80°C
Storage Conditions
Stable for at least 12 months at -80°C. Protect from light. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Calculated Molecular Weight
Heavy Chain: 51 kDa, Light Chain: 27 kDa
Formulation
8 mM Phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
CAS Number
9007-83-4
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