XL-888

XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other diverse kinases with IC50 more than 3600 nM for all. In recent studies, XL-888 has exhibits strong anti-proliferative activities in a panel of tumor cells with values of IC50 ranging from 0.1 nM to 45.5 nM.

Product Specifications

Background

X-ray crystallographic analysis reveals that the XL-888 binds to HSP90 through the formation of H-bonding between the N- (R) -sec-butylanthranilamide moiety of XL-888 and ASP93 of HSP90.

CAS Number

1149705-71-4

Solubility

Soluble in DMSO

Molecular Formula

C29H37N5O3

Shipping Conditions

Room Temperature (continental US) or Gel Packs

Storage Conditions

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.