XL-888
XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other diverse kinases with IC50 more than 3600 nM for all. In recent studies, XL-888 has exhibits strong anti-proliferative activities in a panel of tumor cells with values of IC50 ranging from 0.1 nM to 45.5 nM.
Product Specifications
Background
X-ray crystallographic analysis reveals that the XL-888 binds to HSP90 through the formation of H-bonding between the N- (R) -sec-butylanthranilamide moiety of XL-888 and ASP93 of HSP90.
CAS Number
1149705-71-4
Solubility
Soluble in DMSO
Molecular Formula
C29H37N5O3
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
503.6 Da
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