ML161
Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1) -mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets) .
Product Specifications
Background
ML-161 is thought to act allosterically. ML-161 inhibits thrombin-induced platelet activation.
CAS Number
423735-93-7
Purity
≥ 97%
Solubility
Insoluble in H2O; ≥ 16.4 mg/mL in DMSO; ≥ 46.9 mg/mL in EtOH with ultrasonic. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.
Molecular Formula
C17H17BrN2O2
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
361.2 Da
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