WP1130
A partially-selective, cell permeable DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR) . Typical concentration for cell culture experiments is 5 μM.
Product Specifications
CAS Number
856243-80-6
Applications
Suitable for cell-based studies of USP function.
Purity
≥ 98% by TLC.
Format
Pale yellow powder
Solubility
Soluble in DMSO (45 mg/mL) ; Ethanol (25 mg/mL)
Molecular Formula
C19H18BrN3O
Shipping Conditions
Room Temperature or Gel Packs
Calculated Molecular Weight
384.3 Da
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