SMER3
Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 μM.
Product Specifications
CAS Number
67200-34-4
Applications
Useful for the inhibition of SCFMET30 in cell-based orin vitroassays.
Purity
> 98% by TLC.
Format
Yellow powder
Solubility
Soluble in DMSO (up to 20 mg/mL, with heating)
Molecular Formula
C11H4N4O2S
Shipping Conditions
Room Temperature or Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.
Calculated Molecular Weight
224.2 Da
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