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PYR-41

PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM) . It blocks degradation of p53 and inhibits NF-kappaB-dependent pathways. PYR-41 also increases SUMOylation of proteins.

Product Specifications

CAS Number

418805-02-4

Applications

Useful for inhibition of E1 ubiquitin conjugating enzymes

Purity

> 98% by TLC.

Format

Brown powder

Solubility

Soluble in DMSO (100 mM)

Molecular Formula

C17H13N3O7

Shipping Conditions

Room Temperature or Gel Packs

Storage Conditions

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.

Calculated Molecular Weight

371.3 Da

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