PYR-41
PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM) . It blocks degradation of p53 and inhibits NF-kappaB-dependent pathways. PYR-41 also increases SUMOylation of proteins.
Product Specifications
CAS Number
418805-02-4
Applications
Useful for inhibition of E1 ubiquitin conjugating enzymes
Purity
> 98% by TLC.
Format
Brown powder
Solubility
Soluble in DMSO (100 mM)
Molecular Formula
C17H13N3O7
Shipping Conditions
Room Temperature or Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Calculated Molecular Weight
371.3 Da
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog