PR-619
PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 μM range. Additionally, PR-619 is cell permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.
Product Specifications
CAS Number
2645-32-1
Applications
Useful for non-specific inhibition of ubiquitin-like isopeptidases for cell biology and drug discovery studies.
Purity
≥ 95% by HPLC.
Format
Dry powder
Solubility
Soluble in DMSO (10 mM)
Molecular Formula
C7H5N5S2
Shipping Conditions
Room Temperature
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 3 months. Avoid freeze/thaw cycles of solutions.
Calculated Molecular Weight
223.3 Da
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