DBeQ
DBeQ is cell permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities) . Ki=3.2 μM. DBeQ blocks both ubiquitin dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.
Product Specifications
Applications
Useful for the study of the ubiquitin-dependent and endoplasmic reticulum-associated degradation pathway (p97 ATPase)
Purity
> 98% by TLC.
Format
Yellow powder
Solubility
Soluble in DMSO (25 mg/mL)
Molecular Formula
C22H20N4
Shipping Conditions
Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.
Calculated Molecular Weight
340.4 Da
CAS Number
177355-84-9
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