Celastrol
Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM) . It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM) . Cell permeable.This product has beencited 1 time.
Product Specifications
CAS Number
34157-83-0
Applications
Useful for inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity.
Purity
> 98% by TLC.
Format
Red powder
Solubility
Soluble in DMSO (45 mg/mL) or Ethanol (30 mg/mL)
Molecular Formula
C29H38O4
Shipping Conditions
Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.
Calculated Molecular Weight
450.6 Da
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