What is the catalog number for UPF 1069?

The catalog number for UPF 1069 is 27665-1.

What sizes are available for UPF 1069?

UPF 1069 is available in the following size(s): 10 mg.

Is UPF 1069 in stock?

UPF 1069 is currently made to order / not held in immediate stock. Contact us for lead time.

UPF 1069

UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly- (ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.

Product Specifications

CAS Number

1048371-03-4

Purity

≥ 98% by HPLC

Solubility

Soluble in DMSO

Molecular Formula

C17H13NO3

Shipping Conditions

Room Temperature (continental US) or Gel Packs

Storage Conditions

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.