S- (+) -Rolipram
S- (+) -Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Product Specifications
Background
Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S- (+) -Rolipram enantiomer is 2-10x less potent than the R- (-) -Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
CAS Number
85416-73-5
Molecular Formula
C16H21NO3
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
275.3 Da
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