JW 55

Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway

Product Specifications

Background

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2) . Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

CAS Number

664993-53-7

Purity

≥ 98% by HPLC

Solubility

Soluble in DMSO

Molecular Formula

C25H26N2O5

Shipping Conditions

Room Temperature (continental US) or Gel Packs

Storage Conditions

Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.

Calculated Molecular Weight

434.5 Da