Dicer, FLAG-Tag Recombinant
Recombinant human Dicer (Endoribonuclease Dicer), full length, encompassing amino acids 2-1922 (end) . This construct contains an N-terminal Flag-tag. The recombinant protein was affinity purified.
Product Specifications
Background
Dicer (also known as endoribonuclease Dicer or helicase with RNase motif) is a ribonuclease that participates in pre-microRNA (pre-miRNA) and double stranded RNA (dsRNA) cleavage. The cleavage of pre-miRNA into mature miRNA and formation of small interfering RNA (siRNA) from dsRNA are essential for gene regulation and DNA repair. Decreased levels of Dicer can result in Age-related Macular Degeneration (AMD), the most common age-related blindness. Dicer impairment is also involved in cancer and RNA-based viral infection. The development of small molecule inhibitors or other strategies that affect Dicer activity can provide new therapeutical avenues for cancer treatment and AMD prevention.
CAS Number
9000-83-3
UniProt
Q9UPY3
Tag
N-terminal FLAG-tag
Purity
≥ 85%
Format
Aqueous buffer solution
Shipping Conditions
-80°C
Storage Conditions
At least 6 months at -80°C.
Calculated Molecular Weight
220 kDa
Formulation
40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, and 20% glycerol
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