BAY-1436032
BAY-1436032 is a novel pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor.
Product Specifications
CAS Number
[1803274-65-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BAY-1436032.html
Purity
99.79
Solubility
DMSO : 125 mg/mL (ultrasonic; warming)
Smiles
O=C(O)CCC1=CC=C2C(N=C(NC3=CC=C(OC(F)(F)F)C=C3)N2[C@H]4CC(C)(C)C[C@@H](C)C4)=C1
Molecular Formula
C26H30F3N3O3
Molecular Weight
489.53
Precautions
H302, H315, H319
References & Citations
[1]Chaturvedi A, et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. Leukemia. 2017 Oct;31 (10) :2020-2028.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
IDH1
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
E2281Mo-03 5x 96 Tests
Mouse Myosin light chain kinase, smooth muscle, MYLK ELISA KIT
Ask
View Details