Anti-CD28 Agonist Antibody (Humanized)
Recombinant agonist monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.
Product Specifications
Background
The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody.
CAS Number
9007-83-4
UniProt
P10747
Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
Stable for at least 12 months at -80°C.
Calculated Molecular Weight
Heavy Chain: 50 kDa; Light Chain: 24 kDa
Formulation
8 mM Na Phosphate pH 7.4,110 mM NaCl, 2.2 mM KCl and 20% glycerol
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