Spike Neutralizing Antibody (Clone G10xA1) (SARS-CoV-2)

This monoclonal antibody recognizes the SARS-CoV-2 Spike (B.1.1.529, Omicron Variant) RBD Domain and the S1+S2 trimeric complex to neutralize its interaction with ACE2 [Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Spike protein. This neutralizing antibody has been functionally tested using the SARS-CoV-2 Spike RBD (B.1.1.529, Omicron Variant) :ACE2 Inhibitor Screening Colorimetric Assay Kit (BPS Bioscience #78339) .

Product Specifications

CAS Number

9007-83-4

Applications

This product is for research use only. It is not suitable for human, diagnostic or therapeutic use. The monoclonal neutralizing IgG can be used for functional assays to block SARS-CoV-2 Spike protein and ACE2 binding.

Purification

Protein A affinity chromatography

Format

Aqueous buffer solution

Shipping Conditions

-20°C (Gel Packs or Dry Ice)

Storage Conditions

Store in aliquots at -20°C. Stable for at least 6 months from date of receipt.

Calculated Molecular Weight

~150 kDa

Specificity

The antibody recognizes the B.1.1.529 Omicron variant RBD domain and the S1+S2 trimeric protein. It has not been tested on other spike variants, or on the S1 subunit.