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Anti-VISTA Neutralizing Antibody

This human monoclonal antibody recognizes human V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA), and neutralizes its interaction with VSIG3 (also called IGSF11) . VISTA is also known as B7-H5 or VSIR (GenBank Accession No. NM_022153) . VSIG3 is a ligand involved in cell adhesion as a VISTA binding partner. This neutralizing antibody has been functionally tested using the “VSIG-3:VISTA [Biotinylated] Inhibitor Screening Assay Kit” (BPS Bioscience #79782) .

Product Specifications

CAS Number

9007-83-4

UniProt

Q9H7M9

Applications

This product is for research use only.  It is not suitable for human, diagnostic or therapeutic use. The human monoclonal neutralizing IgG can be used for functional assays to block VISTA and VSIG3 binding

Format

Aqueous buffer solution

Shipping Conditions

-80°C

Storage Conditions

Store in aliquots at -80°C.  Stable for at least 12 months from date of receipt.

Calculated Molecular Weight

~150 kDa

Specificity

The antibody recognizes a unique epitope on the surface of human VISTA protein.  It has not been tested on other species

Formulation

8 mM phosphate pH 7.4,110 mM NaCl, 2.2 mM KCl, 20% glycerol

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